Pigment epithelium derived factor drives melanocyte proliferation and migration in neurofibromatosis café au lait macules

• Main Authors: Charlotte Lovatt (Author), Megan Williams (Author), Alex Gibbs (Author), Abdullahi Mukhtar (Author), Huw J. Morgan (Author), Simone Lanfredini (Author), Carlotta Olivero (Author), Gill Spurlock (Author), Sally Davies (Author), Charlotte Philpott (Author), Hannah Tovell (Author), Peter Turnpenny (Author), Dilair Baban (Author), Sam Knight (Author), Hilde Brems (Author), Julian R. Sampson (Author), Eric Legius (Author), Meena Upadhyaya (Author), Girish K. Patel (Author)
• Format: Book
• Published: Wiley, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background RASopathies, which include neurofibromatosis type 1 (NF1), are defined by Ras/mitogen‐activated protein kinase (Ras/MAPK) pathway activation. They represent a group of clinically related disorders often characterised by multiple Café au Lait Macules (CALMs). Objectives To determi...