Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice

• Main Authors: Jordan R. Yaron (Author), Hao Chen (Author), Sriram Ambadapadi (Author), Liqiang Zhang (Author), Amanda M. Tafoya (Author), Barbara H. Munk (Author), Dara N. Wakefield (Author), Jorge Fuentes (Author), Bruno J. Marques (Author), Krishna Harripersaud (Author), Mee Yong Bartee (Author), Jennifer A. Davids (Author), Donghang Zheng (Author), Kenneth Rand (Author), Lisa Dixon (Author), Richard W. Moyer (Author), William L. Clapp (Author), Alexandra R. Lucas (Author)
• Format: Book
• Published: BMC, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ischemia-reperfusion injury (IRI) is an antigen-independent, innate immune response to arterial occlusion and ischemia with subsequent paradoxical exacerbation after reperfusion. IRI remains a critical problem after vessel occlusion and infarction or during harvest and surgery in...