MiR-125b-5p ameliorates hypoxia/reoxygenation-induced endothelial cell dysfunction and attenuates reduced uterine perfusion pressure-induced hypertension in pregnant rats via targeting BMF
Background and Purpose MicroRNA-125b-5p (miR-125b-5p) is downregulated in patients with gestational hypertension signs. However, the role of miR-125b-5p in pregnancy-induced hypertension (PIH) remains unknown. Methods The human placental microvascular endothelial cells (HPMECs) have undergone hypoxi...
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Taylor & Francis Group,
2022-04-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_2a7bc8ff97cf47d9af2866dbc7a4417d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Haoyu Zheng |e author |
| 700 | 1 | 0 | |a Zhou Yu |e author |
| 700 | 1 | 0 | |a Hairong Wang |e author |
| 700 | 1 | 0 | |a Hongxue Liu |e author |
| 700 | 1 | 0 | |a Xiaoqin Chen |e author |
| 245 | 0 | 0 | |a MiR-125b-5p ameliorates hypoxia/reoxygenation-induced endothelial cell dysfunction and attenuates reduced uterine perfusion pressure-induced hypertension in pregnant rats via targeting BMF |
| 260 | |b Taylor & Francis Group, |c 2022-04-01T00:00:00Z. | ||
| 500 | |a 1064-1955 | ||
| 500 | |a 1525-6065 | ||
| 500 | |a 10.1080/10641955.2022.2036753 | ||
| 520 | |a Background and Purpose MicroRNA-125b-5p (miR-125b-5p) is downregulated in patients with gestational hypertension signs. However, the role of miR-125b-5p in pregnancy-induced hypertension (PIH) remains unknown. Methods The human placental microvascular endothelial cells (HPMECs) have undergone hypoxia and reoxygenation (H/R) treatment to establish PIH cellular model. Rats were performed with reduced uterine perfusion pressure (RUPP) operation to establish PIH animal model. Results MiR-125b-5p promoted viability while inhibited the apoptosis of H/R-treated HPMECs by downregulating BMF. MiR-125b-5p alleviated hypertensive symptoms and improved pregnancy outcomes in RUPP rats. Conclusion MiR-125b-5p ameliorates H/R-induced HPMEC dysfunction and attenuates RUPP-induced hypertension in pregnant rats by downregulating BMF. | ||
| 546 | |a EN | ||
| 690 | |a mir-125b-5p | ||
| 690 | |a bmf | ||
| 690 | |a human placental microvascular endothelial cells | ||
| 690 | |a pregnancy-induced hypertension | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Hypertension in Pregnancy, Vol 41, Iss 2, Pp 79-88 (2022) | |
| 787 | 0 | |n http://dx.doi.org/10.1080/10641955.2022.2036753 | |
| 787 | 0 | |n https://doaj.org/toc/1064-1955 | |
| 787 | 0 | |n https://doaj.org/toc/1525-6065 | |
| 856 | 4 | 1 | |u https://doaj.org/article/2a7bc8ff97cf47d9af2866dbc7a4417d |z Connect to this object online. |