Nitrosamines crisis in pharmaceuticals − Insights on toxicological implications, root causes and risk assessment: A systematic review

• Main Authors: Hemanth P.R. Vikram (Author), Tegginamath Pramod Kumar (Author), Gunjan Kumar (Author), Narasimha M. Beeraka (Author), Rajashree Deka (Author), Sheik Mohammed Suhail (Author), Sandeep Jat (Author), Namitha Bannimath (Author), Gayatiri Padmanabhan (Author), Ravandur S. Chandan (Author), Pramod Kumar (Author), Bannimath Gurupadayya (Author)
• Formato: Livro
• Publicado em: Elsevier, 2024-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The presence of N-nitroso compounds, particularly N-nitrosamines, in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic effects. This systematic review investigates their toxicity in active pharmaceutical ingredients (APIs), drug products, and...