Synthesis and Antiproliferative Activity of Novel Heterocyclic Indole-Trimethoxyphenyl Conjugates

• Main Authors: Michael M. Cahill (Author), Kevin D. O'Shea (Author), Larry T. Pierce (Author), Hannah J. Winfield (Author), Kevin S. Eccles (Author), Simon E. Lawrence (Author), Florence O. McCarthy (Author)
• Format: Book
• Published: MDPI AG, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The synthesis and biological evaluation of a series of novel heterocyclic indole derivatives is described. The consolidation of the combretastatin and bisindolylmaleimide templates towards the inclusion of a novel heterocyclic ring proffered a versatile pharmacophore with which to pursue chemical di...