Synthesis and Antiproliferative Activity of Novel Heterocyclic Indole-Trimethoxyphenyl Conjugates

• Autori principali: Michael M. Cahill (Autore), Kevin D. O'Shea (Autore), Larry T. Pierce (Autore), Hannah J. Winfield (Autore), Kevin S. Eccles (Autore), Simon E. Lawrence (Autore), Florence O. McCarthy (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2017-07-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The synthesis and biological evaluation of a series of novel heterocyclic indole derivatives is described. The consolidation of the combretastatin and bisindolylmaleimide templates towards the inclusion of a novel heterocyclic ring proffered a versatile pharmacophore with which to pursue chemical di...