Synthesis, Biological, and Computational Evaluation of Antagonistic, Chiral Hydrobenzoin Esters of Arecaidine Targeting mAChR M1

• Main Authors: Marius Ozenil (Author), Jonas Aronow (Author), Daniela Piljak (Author), Chrysoula Vraka (Author), Wolfgang Holzer (Author), Helmut Spreitzer (Author), Wolfgang Wadsak (Author), Marcus Hacker (Author), Verena Pichler (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Muscarinic acetylcholine receptors (mAChRs) are a pivotal constituent of the central and peripheral nervous system. Yet, therapeutic and diagnostic applications thereof are hampered by the lack of subtype selective ligands. Within this work, we synthesized and chemically characterized three differen...