Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick
Abstract Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
BMC,
2021-12-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Abstract Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has led to the definition of a stem cell leukemia with a combined lymphoid-myeloid potential: the perfect trick. Several studies in the last decade aimed to better characterize this new disease, but it was recognized as a distinct entity only in 2016. We review current insights into the biology of ETP-ALL and discuss the pathogenesis, genomic features and their impact on the clinical course in the precision medicine era today. |
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| Item Description: | 10.1186/s40364-021-00347-z 2050-7771 |