Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion

• Main Authors: Alexandre Picard (Author), Xavier Berney (Author), Judit Castillo-Armengol (Author), David Tarussio (Author), Maxime Jan (Author), Ana Rodriguez Sanchez-Archidona (Author), Sophie Croizier (Author), Bernard Thorens (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Glucagon secretion to stimulate hepatic glucose production is the first line of defense against hypoglycemia. This response is triggered by so far incompletely characterized central hypoglycemia-sensing mechanisms, which control autonomous nervous activity and hormone secretion. The obje...