Intravascular large B-cell lymphoma involving pleural solitary fibrous tumor: A case report and literature review

• Main Authors: Amintas Samuel (Author), Laurent Elodie (Author), Gros Audrey (Author), Sesboue Come (Author), Merlio Jean-Philippe (Author), Parrens Marie (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2214-3300; 10.1016/j.ehpc.2021.200530
• Keywords: Intravascular large B-cell lymphoma; B-cell lymphoma; Malignant solitary fibrous tumor; Synchronous cancers; Pathology; RB1-214
• Source: Human Pathology: Case Reports, Vol 25, Iss , Pp 200530- (2021)

Intravascular large B-cell lymphoma (IVLBCL) is a very rare type of extranodal large B-cell lymphoma that selectively grows within vessels and can spread to any organs or tissues. A very few cases of synchronicity with malignant tumor have yet been described. We report a rare case of IVLBCL accompanying a pleural malignant solitary fibrous tumor (MSFT). A 76-year-old man presented with a chronic dry cough, fever, minor general state deterioration and pancytopenia. Imaging revealed a large pleural mass. Histologically, the mass consisted of a MSFT. However, CD20+ malignant round cells were scattered within lumina of intratumoral blood vessels, evidencing a synchronous IVLBCL occurrence. Molecular analysis of the lymphoid clone identified MYD88 and CD79B gene mutations. After pleural mass excision, global health's patient improved with cytopenia correction. However, a general state deterioration appeared 4 months after surgery, associated with a large retroperitoneal mass presenting the same pathological and molecular patterns identical to the initial IVLBCL clone.