A Workflow for Global Sensitivity Analysis of PBPK Models

• Main Authors: Kevin eMcNally (Author), Richard eCotton (Author), George D Loizou (Author)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2011-06-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Physiologically based pharmacokinetic models have a potentially significant role in the development of a reliable predictive toxicity testing strategy. The structure of PBPK models are ideal frameworks into which disparate in vitro and in vivo data can be integrated and utilised to translate informa...