Patterns of antimicrobial resistance in a pediatric cardiac intensive care unit

• Autore principale: Nelya Bissenova (Autore)
• Natura: Libro
• Pubblicazione: National Scientific Medical Center, 2017-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.
• Notes: 1812-2892; 2313-1519; 10.23950/1812-2892-JCMK-00382
• Keywords: antimicrobial resistance; pediatric cardiac intensive care unit; microbiological monitoring; Klebsiella pneumoniae; Pseudomonas aeruginosa; Internal medicine; RC31-1245; Specialties of internal medicine; RC581-951
• Source: Ķazaķstannyṇ Klinikalyķ Medicinasy, Vol 2, Iss 44, Pp 27-32 (2017)

<b>Objective:</b> to report the antibiotic resistance rate of most frequently pathogens in pediatric cardiac intensive care unit (PCICU) during a fve-year period.<br> <b>Methods.</b> A prospective study was performed on 4228 clinical samples (bloodstream, wound samples, respiratory tract, tracheobronchial tree, and central venous catheter) from patients in PCICU during the period 2012-2016. Identifcation of isolates and antibiotic susceptibility testing were performed by Vitek 2 automated system.<br> <b>Results.</b> The percentages of most frequently isolated microorganisms in our PCICU were as follows: Klebsiella pneumoniae 8.9%, Pseudomonas aeruginosa 7.5%, Staphylococcus aureus 6.9%, coagulase negative staphylococci 5.3%, and Candida sp. 3.4%. During study period there is tendency increasing the percentage of detection Ps.aeruginosa from 2.6% to 10.8% (p=0.018), K.pneumoniae from 2.6% to 10.5% (p=0.023), and Candida sp. from 1.6% to 5.9% (p=0.033). These isolates showed tendency of signifcant increasing resistance to 3rd generation cephalosporins and carbapenems.<br> <b>Conclusion.</b> The present study reported that most frequent isolates in our PCICU were Ps.aeruginosa and K.pneumoniae. Reporting of dramatically increasing resistance rates of these isolates necessitates a well-designed hospital infection control strategy, including good hygiene, microbiological monitoring; all of this will greatly reduce the risk of nosocomial infection.