Characterization of 1H NMR and 13C NMR Spectrometry and Antibacterial Activities of 4-tert-Butylbenzoyl Amoxicillin

• Main Authors: Hadi Barru Hakam Fajar Siddiq (Author), Dewi Rashati (Author), Siti Nur Azizah (Author)
• Format: Book
• Published: Universitas Sanata Dharma, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1693-5683; 2527-7146; 10.24071/jpsc.002183
• Keywords: 4-tert-butylbenzoyl amoxicillin; bacillus subtilis; escherichia coli; spectrometry; staphylococcus aureus; Pharmacy and materia medica; RS1-441
• Source: Jurnal Farmasi Sains dan Komunitas, Vol 19, Iss 1, Pp 29-33 (2022)

The synthesis of 4-tert-butylbenzoyl amoxicillin has been done by reacting amoxicillin with 4-tert-butylbenzoyl chloride. The product was characterized using proton and carbon-13 spectrometry. Antibacterial activity of 4-tert-butylbenzoyl amoxicillin against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus was tested using paper disk diffusion method. Results showed that 4-tert-butylbenzoyl amoxicillin had a specific spectrum activity. Antibacterial test of 4-tert-butylbenzoyl amoxicillin showed clear zones around the disc paper for Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. The study results indicated 4-tert-butylbenzoyl amoxicillin has antimicrobial properties but is categorized as a less-effective antibiotic agent based on the response to bacterial growth inhibition.