Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia

• Main Authors: Kristine Pettersen (Author), Sonja Andersen (Author), Anna van derVeen (Author), Unni Nonstad (Author), Shinji Hatakeyama (Author), Christian Lambert (Author), Estelle Lach‐Trifilieff (Author), Siver Moestue (Author), Jana Kim (Author), Bjørn Henning Grønberg (Author), Alain Schilb (Author), Carsten Jacobi (Author), Geir Bjørkøy (Author)
• Format: Book
• Published: Wiley, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The majority of patients with advanced cancer develop cachexia, a weight loss syndrome that severely reduces quality of life and limits survival. Our understanding of the underlying mechanisms that cause the condition is limited, and there are currently no treatment options that...