PAMAM-Calix-Dendrimers: Third Generation Synthesis and Impact of Generation and Macrocyclic Core Conformation on Hemotoxicity and Calf Thymus DNA Binding

• Main Authors: Olga Mostovaya (Author), Igor Shiabiev (Author), Daniil Ovchinnikov (Author), Dmitry Pysin (Author), Timur Mukhametzyanov (Author), Alesia Stanavaya (Author), Viktar Abashkin (Author), Dzmitry Shcharbin (Author), Arthur Khannanov (Author), Marianna Kutyreva (Author), Mingwu Shen (Author), Xiangyang Shi (Author), Pavel Padnya (Author), Ivan Stoikov (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background/Objectives</b>: Current promising treatments for many diseases are based on the use of therapeutic nucleic acids, including DNA. However, the list of nanocarriers is limited due to their low biocompatibility, high cost, and toxicity. The design of synthetic building blocks...