In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats

• Main Authors: Sandy Van Hemelryck (Author), Jonatan Dewulf (Author), Harm Niekus (Author), Marjolein van Heerden (Author), Benno Ingelse (Author), René Holm (Author), Erik Mannaert (Author), Peter Langguth (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The objective of this study was to evaluate in vitro and in vivo drug release from in situ forming gels prepared with poloxamer 338 (P338) and/or 407 (P407) in N-methyl-2-pyrrolidone (NMP)/water mixtures for the model compound bedaquiline fumarate salt. The impact of total poloxamer concentration (2...