Seladoeneolignan A, a new neolignan from Selaginella doederleinii Hieron.
Objective: To study the chemical compositions from Selaginella doederleinii Hieron. Methods: The petroleum ether and ethyl acetate fractions of 80% ethanol extract of S. doederleinii were separated and purified by macroporous resin, silica gel, Sephadex LH-20 and semi-preparative HPLC, and then the...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Book |
| Published: |
KeAi Communications Co., Ltd.,
2022-09-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Objective: To study the chemical compositions from Selaginella doederleinii Hieron. Methods: The petroleum ether and ethyl acetate fractions of 80% ethanol extract of S. doederleinii were separated and purified by macroporous resin, silica gel, Sephadex LH-20 and semi-preparative HPLC, and then the structures of obtained compounds were identified by physicochemical properties and spectroscopical data. Results: A total of 7 compounds were isolated and identified as seladoeneolignan A (1), ethoxy-ferulate (2), 11-dien-19-oic acid (3), aurantiamide (4), 9,16-dioxo-10,12,14-octadeca-trienoic acid (5), amentoflavone (6), and 7,4'-di-0-methylrobustaflavone (7). Conclusion: Compound 1 was a new neolignan obtaind from S. doederleinii for the first time. Compounds 1, 6 and 7 were screened for antitumor activity in vitro, and the testing results showed that 3 compounds had low inhibitory activity on Hep-2 and Eca-109 tumor cells. |
|---|---|
| Item Description: | 2707-3688 10.1016/S2707-3688(23)00042-0 |