CC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin's lymphoma

• Үндсэн зохиолчид: Dan Zhu (Зохиогч), Haralambos Hadjivassiliou (Зохиогч), Catherine Jennings (Зохиогч), David Mikolon (Зохиогч), Massimo Ammirante (Зохиогч), Sharmistha Acharya (Зохиогч), Jon Lloyd (Зохиогч), Mahan Abbasian (Зохиогч), Rama Krishna Narla (Зохиогч), Joseph R. Piccotti (Зохиогч), Katie Stamp (Зохиогч), Ho Cho (Зохиогч), Kandasamy Hariharan (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

ABSTRACTCluster of differentiation 47 (CD47) is a transmembrane protein highly expressed in tumor cells that interacts with signal regulatory protein alpha (SIRPα) and triggers a "don't eat me" signal to the macrophage, inhibiting phagocytosis and enabling tumor escape from immunosurv...