CC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin's lymphoma

• Autores principales: Dan Zhu (Autor), Haralambos Hadjivassiliou (Autor), Catherine Jennings (Autor), David Mikolon (Autor), Massimo Ammirante (Autor), Sharmistha Acharya (Autor), Jon Lloyd (Autor), Mahan Abbasian (Autor), Rama Krishna Narla (Autor), Joseph R. Piccotti (Autor), Katie Stamp (Autor), Ho Cho (Autor), Kandasamy Hariharan (Autor)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

ABSTRACTCluster of differentiation 47 (CD47) is a transmembrane protein highly expressed in tumor cells that interacts with signal regulatory protein alpha (SIRPα) and triggers a "don't eat me" signal to the macrophage, inhibiting phagocytosis and enabling tumor escape from immunosurv...