Prenatal antidepressant exposure and emotional disorders until age 22: a danish register study

Abstract Background Selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed antidepressants in pregnancy. Animal and some clinical studies have suggested potential increases in depression and anxiety following prenatal SSRI exposure, but the extent to which these are drive...

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Main Authors: Mette Bliddal (Author), Rikke Wesselhoeft (Author), Katrine Strandberg-Larsen (Author), Martin T. Ernst (Author), Myrna M. Weissman (Author), Jay A. Gingrich (Author), Ardesheer Talati (Author), Anton Pottegård (Author)
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Published: BMC, 2023-06-01T00:00:00Z.
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001 doaj_2bc64d6b347647f28e2855c0a7bc3b93
042 |a dc 
100 1 0 |a Mette Bliddal  |e author 
700 1 0 |a Rikke Wesselhoeft  |e author 
700 1 0 |a Katrine Strandberg-Larsen  |e author 
700 1 0 |a Martin T. Ernst  |e author 
700 1 0 |a Myrna M. Weissman  |e author 
700 1 0 |a Jay A. Gingrich  |e author 
700 1 0 |a Ardesheer Talati  |e author 
700 1 0 |a Anton Pottegård  |e author 
245 0 0 |a Prenatal antidepressant exposure and emotional disorders until age 22: a danish register study 
260 |b BMC,   |c 2023-06-01T00:00:00Z. 
500 |a 10.1186/s13034-023-00624-9 
500 |a 1753-2000 
520 |a Abstract Background Selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed antidepressants in pregnancy. Animal and some clinical studies have suggested potential increases in depression and anxiety following prenatal SSRI exposure, but the extent to which these are driven by the medication remains unclear. We used Danish population data to test associations between maternal SSRI use during pregnancy and children outcomes up to age 22. Methods We prospectively followed 1,094,202 single-birth Danish children born 1997-2015. The primary exposure was ≥ 1 SSRI prescription filled during pregnancy; the primary outcome, first diagnosis of a depressive, anxiety, or adjustment disorder, or redeemed prescription for an antidepressant medication. We used propensity score weights to adjust potential confounders, and incorporated data from the Danish National Birth Cohort (1997-2003) to further quantify potential residual confounding by subclinical factors. Results The final dataset included 15,651 exposed and 896,818 unexposed, children. After adjustments, SSRI-exposed had higher rates of the primary outcome than those of mothers who either did not use an SSRI (HR = 1.55 [95%CI:1.44,1.67] or discontinued the SSRI use ≥ 3 months prior to conception (HR = 1.23 [1.13,1.34]). Age of onset was earlier among exposed (9 [IQR:7-13] years) versus unexposed (12 [IQR:12-17] years) children (p < 0.01). Paternal SSRI use in the absence of maternal use during the index pregnancy (HR = 1.46 [1.35,1.58]) and maternal SSRI use only after pregnancy (HR = 1.42 [1.35,1.49]) were each also associated with these outcomes. Conclusions While SSRI exposure was associated with increased risk in the children, this risk may be driven at least partly by underlying severity of maternal illness or other confounding factors. 
546 |a EN 
690 |a Depression 
690 |a Antidepressant 
690 |a Selective serotonin reuptake inhibitor (SSRI) 
690 |a Prenatal exposure 
690 |a Birth cohort 
690 |a Propensity score 
690 |a Pediatrics 
690 |a RJ1-570 
690 |a Psychiatry 
690 |a RC435-571 
655 7 |a article  |2 local 
786 0 |n Child and Adolescent Psychiatry and Mental Health, Vol 17, Iss 1, Pp 1-12 (2023) 
787 0 |n https://doi.org/10.1186/s13034-023-00624-9 
787 0 |n https://doaj.org/toc/1753-2000 
856 4 1 |u https://doaj.org/article/2bc64d6b347647f28e2855c0a7bc3b93  |z Connect to this object online.