Systems‐based digital twins to help characterize clinical dose-response and propose predictive biomarkers in a Phase I study of bispecific antibody, mosunetuzumab, in NHL

• Main Authors: Monica E. Susilo (Author), Chi‐Chung Li (Author), Kapil Gadkar (Author), Genevive Hernandez (Author), Ling‐Yuh Huw (Author), Jin Y. Jin (Author), Shen Yin (Author), Michael C. Wei (Author), Saroja Ramanujan (Author), Iraj Hosseini (Author)
• Format: Book
• Published: Wiley, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Phase I oncology clinical trials often comprise a limited number of patients representing different disease subtypes who are divided into cohorts receiving treatment(s) at different dosing levels and schedules. Here, we leverage a previously developed quantitative systems pharmacology model...