Systems‐based digital twins to help characterize clinical dose-response and propose predictive biomarkers in a Phase I study of bispecific antibody, mosunetuzumab, in NHL

Abstract Phase I oncology clinical trials often comprise a limited number of patients representing different disease subtypes who are divided into cohorts receiving treatment(s) at different dosing levels and schedules. Here, we leverage a previously developed quantitative systems pharmacology model...

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Main Authors: Monica E. Susilo (Author), Chi‐Chung Li (Author), Kapil Gadkar (Author), Genevive Hernandez (Author), Ling‐Yuh Huw (Author), Jin Y. Jin (Author), Shen Yin (Author), Michael C. Wei (Author), Saroja Ramanujan (Author), Iraj Hosseini (Author)
Format: Book
Published: Wiley, 2023-07-01T00:00:00Z.
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