Associations of advanced age with comorbidity, stage and primary subsite as contributors to mortality from colorectal cancer

BackgroundAlthough survival from colorectal cancer (CRC) has improved substantially in recent decades, people with advanced age still have a high likelihood of mortality from this disease. Nonetheless, few studies have investigated how cancer stage, subsite and comorbidities contribute collectively...

Full description

Saved in:
Bibliographic Details
Main Authors: Kazzem Gheybi (Author), Elizabeth Buckley (Author), Agnes Vitry (Author), David Roder (Author)
Format: Book
Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000 am a22000003u 4500
001 doaj_2bcff5a265fd42c3b1a6dc270f161741
042 |a dc 
100 1 0 |a Kazzem Gheybi  |e author 
700 1 0 |a Kazzem Gheybi  |e author 
700 1 0 |a Kazzem Gheybi  |e author 
700 1 0 |a Elizabeth Buckley  |e author 
700 1 0 |a Elizabeth Buckley  |e author 
700 1 0 |a Agnes Vitry  |e author 
700 1 0 |a David Roder  |e author 
700 1 0 |a David Roder  |e author 
245 0 0 |a Associations of advanced age with comorbidity, stage and primary subsite as contributors to mortality from colorectal cancer 
260 |b Frontiers Media S.A.,   |c 2023-04-01T00:00:00Z. 
500 |a 2296-2565 
500 |a 10.3389/fpubh.2023.1101771 
520 |a BackgroundAlthough survival from colorectal cancer (CRC) has improved substantially in recent decades, people with advanced age still have a high likelihood of mortality from this disease. Nonetheless, few studies have investigated how cancer stage, subsite and comorbidities contribute collectively to poor prognosis of older people with CRC. Here, we decided to explore the association of age with mortality measures and how other variables influenced this association.MethodsUsing linkage of several administrative datasets, we investigated the risk of death among CRC cases during 2003-2014. Different models were used to explore the association of age with mortality measures and how other variables influenced this association.ResultsOur results indicated that people diagnosed at a young age and with lower comorbidity had a lower likelihood of all-cause and CRC-specific mortality. Aging had a greater association with mortality in early-stage CRC, and in rectal cancer, compared that seen with advanced-stage CRC and right colon cancer, respectively. Meanwhile, people with different levels of comorbidity were not significantly different in terms of their increased likelihood of mortality with advanced age. We also found that while most comorbidities were associated with all-cause mortality, only dementia [SHR = 1.43 (1.24-1.64)], Peptic ulcer disease [SHR = 1.12 (1.02-1.24)], kidney disease [SHR = 1.11 (1.04-1.20)] and liver disease [SHR = 1.65 (1.38-1.98)] were risk factors for CRC-specific mortality.ConclusionThis study showed that the positive association of advanced age with mortality in CRC depended on stage and subsite of the disease. We also found only a limited number of comorbidities to be associated with CRC-specific mortality. These novel findings implicate the need for more attention on factors that cause poor prognosis in older people. 
546 |a EN 
690 |a advanced age 
690 |a mortality 
690 |a comorbidity 
690 |a cancer stage 
690 |a colorectal cancer 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n Frontiers in Public Health, Vol 11 (2023) 
787 0 |n https://www.frontiersin.org/articles/10.3389/fpubh.2023.1101771/full 
787 0 |n https://doaj.org/toc/2296-2565 
856 4 1 |u https://doaj.org/article/2bcff5a265fd42c3b1a6dc270f161741  |z Connect to this object online.