CD8+CXCR5+ T Cells Regulate Pathology in the Genital Tract
We have identified a CD8+CXCR5+ T cell that prevents the development of oviduct dilation following C. muridarum genital infection. Phenotypic studies show that CD8+CXCR5+ cells express markers of T regulatory cells (FoxP3, CD25, and GITR) but do not express a necessary component of cytotoxic cells (...
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| Main Authors: | , , , , |
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| Format: | Book |
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Hindawi Limited,
2013-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | We have identified a CD8+CXCR5+ T cell that prevents the development of oviduct dilation following C. muridarum genital infection. Phenotypic studies show that CD8+CXCR5+ cells express markers of T regulatory cells (FoxP3, CD25, and GITR) but do not express a necessary component of cytotoxic cells (perforin). Cxcr5-/- mice have significantly lower numbers of CD8+ cells and lack the CD8+CXCR5+ population while the total number of CD4+ cells is equivalent between mouse strains. The transfer of CD8+ splenocytes from WT mice reduces the oviduct dilation seen in Cxcr5-/- mice following C. muridarum infection. Future studies will investigate the mechanism by which this cell type regulates genital tract pathology. |
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| Item Description: | 1064-7449 1098-0997 10.1155/2013/813238 |