Estimating utility values for non-alcoholic steatohepatitis health states: a discrete choice experiment
Background: This study estimated utility values for non-alcoholic steatohepatitis (NASH). Previous studies have assumed that health-related quality of life does not vary between the early stages of NASH. Materials &Methods: Discrete choice experiment (DCE) surveys estimated the value of avoiding...
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| Main Authors: | , , , , |
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| Format: | Book |
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Becaris Publishing Limited,
2024-01-01T00:00:00Z.
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| Summary: | Background: This study estimated utility values for non-alcoholic steatohepatitis (NASH). Previous studies have assumed that health-related quality of life does not vary between the early stages of NASH. Materials &Methods: Discrete choice experiment (DCE) surveys estimated the value of avoiding fibrosis progression. Patients also completed the EQ-5D-5L. Marginal rates of substitution estimated utility change associated with fibrosis progression. Results: DCE surveys were completed by the UK general public (n = 520) and patients with NASH (n = 154). The utility decline between fibrosis stages F1 and F4 decompensated was between -0.521 to -0.646 (depending on method). Conclusion: Three methods were used to estimate utilities for NASH, each one showed sensitivity to advancing fibrosis, including in the early stages, which is often considered asymptomatic. |
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| Item Description: | 10.57264/cer-2023-0033 2042-6313 |