Characteristics of non-small cell lung cancer: Differences by sex and hormonal status in a Mexican population

• Main Authors: Vianey Rodríguez-Lara (Author), Laura Alejandra Ramírez-Tirado (Author), Feliciano Barrón (Author), Zyanya Lucía Zatarain-Barrón (Author), Diana Flores-Estrada (Author), Oscar Arrieta (Author)
• Format: Book
• Published: Instituto Nacional de Salud Pública, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Objective. To analyze the differences in the clinico-patho­logical and molecular characteristics of non-small cell lung cancer (NSCLC) as well as the clinical outcome of patients by sex and hormonal status. Materials and methods. We performed a retrospective study among 1 104 NSCLC patients. Clinic-pathologic data was recorded and survival outcomes were compared between male and female sex patients, and further by pre and postmenopausal status in fe­males. Results. Women were significantly more likely to be non-smokers (p<0.001), had higher frequency of wood-smoke exposure (p<0.001), EGFR-sensitizing mutations (p<0.001), had better performance status (p=0.020) and had a better overall survival (OS) compared to men (p=0.021). Differences were found also by hormonal status, postmenopausal women had a longer OS compared to premenopausal women (31.1 vs. 19.4 months p=0.046). Conclusion. Our results support the differences in lung cancer presentation by sex and also by hormonal status.

Item Description

0036-3634
10.21149/10094