Soluble immune checkpoint molecules in cancer risk, outcomes prediction, and therapeutic applications
Abstract Immunotherapy has emerged as a pivotal modality in cancer treatment, with immune checkpoint inhibitors effectively combating malignancies by impeding crucial pathways within the immune system and stimulating patients' immune responses. Soluble forms of immune checkpoints exhibit a rema...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Book |
| Published: |
BMC,
2024-09-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_2c7e8ff01c2c48bbbd8be8950d1d1bc0 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Lin Chen |e author |
| 700 | 1 | 0 | |a Yuqing Chao |e author |
| 700 | 1 | 0 | |a Wenjing Li |e author |
| 700 | 1 | 0 | |a Zhixia Wu |e author |
| 700 | 1 | 0 | |a Qinchuan Wang |e author |
| 245 | 0 | 0 | |a Soluble immune checkpoint molecules in cancer risk, outcomes prediction, and therapeutic applications |
| 260 | |b BMC, |c 2024-09-01T00:00:00Z. | ||
| 500 | |a 10.1186/s40364-024-00647-0 | ||
| 500 | |a 2050-7771 | ||
| 520 | |a Abstract Immunotherapy has emerged as a pivotal modality in cancer treatment, with immune checkpoint inhibitors effectively combating malignancies by impeding crucial pathways within the immune system and stimulating patients' immune responses. Soluble forms of immune checkpoints exhibit a remarkable diversity and can be readily tracked in circulation, holding immense potential as biomarkers for cancer treatment. An increasing number of studies focused on soluble immune checkpoints in cancer have emerged thanks to technological advancements. In this systematic review, we comprehensively summarized the recent studies on soluble immune checkpoints in human cancer risk prediction, outcome prediction, therapeutic applications, and potential molecular mechanisms, which demonstrated the promising future of soluble immune checkpoints in clinical applications. The clinical relevance of soluble immune checkpoints has been recognized in multiple cancers, yet the therapeutic applications and mechanisms remain obscure. Interpreting the impacts and mechanisms of soluble immune checkpoints could shed a light on the novel strategies of cancer screening, treatments, and outcome prediction. | ||
| 546 | |a EN | ||
| 690 | |a Soluble immune checkpoint protein | ||
| 690 | |a Biomarkers | ||
| 690 | |a Cancer immunotherapy | ||
| 690 | |a Tumor microenvironment | ||
| 690 | |a Cancer risk | ||
| 690 | |a Cancer outcomes | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Biomarker Research, Vol 12, Iss 1, Pp 1-20 (2024) | |
| 787 | 0 | |n https://doi.org/10.1186/s40364-024-00647-0 | |
| 787 | 0 | |n https://doaj.org/toc/2050-7771 | |
| 856 | 4 | 1 | |u https://doaj.org/article/2c7e8ff01c2c48bbbd8be8950d1d1bc0 |z Connect to this object online. |