Is netrin-1 a reliable inflammatory marker for periodontitis?
Background. The current study tested netrin-1 as a reliable inflammatory marker of periodontal disease. Methods. Gingival crevicular fluid (GCF) samples were taken at baseline from 30 systemically healthy individuals. Fifteen subjects had stage II grade A or B periodontitis, and 15 were periodontall...
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| Format: | Book |
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Tabriz University of Medical Sciences,
2022-06-01T00:00:00Z.
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| Summary: | Background. The current study tested netrin-1 as a reliable inflammatory marker of periodontal disease. Methods. Gingival crevicular fluid (GCF) samples were taken at baseline from 30 systemically healthy individuals. Fifteen subjects had stage II grade A or B periodontitis, and 15 were periodontally and clinically healthy. Whole-mouth periodontal parameters [probing depth (PD), clinical attachment loss (CAL), plaque index (PI), and gingival index (GI)] were recorded. The GCF samples were re-collected, and clinical parameters were re-recorded after six weeks following full-mouth scaling and root planing (SRP) in the periodontitis group. Results. Netrin-1 GCF levels were significantly lower in periodontitis patients than periodontally healthy individuals at baseline with a significant increase in netrin-1 GCF levels after SRP (P<0.05). Conclusion. Netrin-1 may have a significant role in the inflammatory process of chronic periodontitis; thus, it could be a promising anti-inflammatory marker in periodontal disease. |
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| Item Description: | 2645-5390 10.34172/japid.2022.001 |