Physiologically-based pharmacokinetic modelling and dosing evaluation of gentamicin in neonates using PhysPK

• Main Authors: Hinojal Zazo (Author), Eduardo Lagarejos (Author), Manuel Prado-Velasco (Author), Sergio Sánchez-Herrero (Author), Jenifer Serna (Author), Almudena Rueda-Ferreiro (Author), Ana Martín-Suárez (Author), M. Victoria Calvo (Author), Jonás Samuel Pérez-Blanco (Author), José M. Lanao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Each year, infections caused around the 25% of neonatal deaths. Early empirical treatments help to reduce this mortality, although optimized dosing regimens are still lacking. The aims were to develop and validate a gentamicin physiologically-based pharmacokinetic (PBPK) model and then potentially e...