A Case of S-Variant Hepatitis B Virus: An Immune System Escape Artist

Genomic variants of the hepatitis B virus (HBV) preS/S protein are well-known to occur. Typically, immunity is gained through recovered HBV infection or by immunization. Very rarely, there are certain mutations that may enable HBV escape from the immune detection. PreS/S mutants may present with unp...

Full description

Saved in:
Bibliographic Details
Main Authors: Amar S. Shah MD (Author), Valerie F. Civelli MD (Author), Varun Bali MD (Author), Royce H. Johnson MD (Author), Arash Heidari MD (Author)
Format: Book
Published: SAGE Publishing, 2021-09-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Genomic variants of the hepatitis B virus (HBV) preS/S protein are well-known to occur. Typically, immunity is gained through recovered HBV infection or by immunization. Very rarely, there are certain mutations that may enable HBV escape from the immune detection. PreS/S mutants may present with unpredictable pathobiologic, clinical, and transmittable implications. Standard laboratory testing for genomic HBV variants is not routinely performed by reference guidelines. s-variant HBV management remains challenging. Herein is a case of s-variant chronic HBV infection in a 55-year-old man. Diagnosis and treatment are described.
Item Description:2324-7096
10.1177/23247096211045450