Cyclosporin-A Treatment in Steroid Nonresponsive Nephrotic Syndrome

• Main Authors: IGN Wila Wirya (Author), Taralan Tambunan (Author), Husein Alatan (Author)
• Format: Book
• Published: Indonesian Pediatric Society Publishing House, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 0030-9311; 2338-476X; 10.14238/pi34.1-2.1994.1-7
• Keywords: cyclosporin-A; nephrotic syndrome; steroid; CyA; Medicine; R; Pediatrics; RJ1-570
• Source: Paediatrica Indonesiana, Vol 34, Iss 1-2, Pp 1-7 (2018)

Fifteen patients with steroid nonresponsive nephrotic syndrome (NS) aged 4-16 years received oral cyclosporin-A (CyA) for 12 weeks. Nine of the patients were boys. Out of the 15 patients, 7 were frequent relapsers, 3 were steroid dependents, 4 were steroid resistants and one with toxic steroid. After 12 weeks of CyA treatment;, 6 patients showed complete remission, 7 showed partial remission, and 2 patients did not respond at all. Side effects observed were slight renal function impairment, gingival hyperplasia, and a hump on the breast; all disappeared gradually after stopping CyA. Patients with total remission experienced relapse 2 to 12 months after discontinuation of CyA, while patients with partial remission experienced relapse 2 weeks to 3 months after CyA was discontinued A tentative conclusion can be drawn that CyA is a good alternative in the treatment of idiopathic NS, especially in steroid dependent patients who are at risk of developing steroid toxicity. CyA represent a major advance in the treatment selected SN patients who have failed with the conventional modes of therapy.