A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy.

• Main Authors: Vinicius M Fava (Author), Jérémy Manry (Author), Aurélie Cobat (Author), Marianna Orlova (Author), Nguyen Van Thuc (Author), Nguyen Ngoc Ba (Author), Vu Hong Thai (Author), Laurent Abel (Author), Alexandre Alcaïs (Author), Erwin Schurr (Author), Canadian Lrrk2 in Inflammation Team (CLINT) (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Depending on the epidemiological setting, a variable proportion of leprosy patients will suffer from excessive pro-inflammatory responses, termed type-1 reactions (T1R). The LRRK2 gene encodes a multi-functional protein that has been shown to modulate pro-inflammatory responses. Variants near the LR...