Treatment with benznidazole and pentoxifylline regulates microRNA transcriptomic profile in a murine model of Chagas chronic cardiomyopathy.

• Main Authors: Priscila Silva Grijó Farani (Author), Beatriz Iandra da Silva Ferreira (Author), Khodeza Begum (Author), Glaucia Vilar-Pereira (Author), Isabela Resende Pereira (Author), Edith A Fernández-Figueroa (Author), Roberto Alejandro Cardenas-Ovando (Author), Igor C Almeida (Author), Sourav Roy (Author), Joseli Lannes-Vieira (Author), Otacilio Cruz Moreira (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic Chagas cardiomyopathy (CCC) is one of the leading causes of morbidity and mortality due to cardiovascular disorders in endemic areas of Chagas disease (CD), a neglected tropical illness caused by the protozoan parasite Trypanosoma cruzi. CCC is characterized by parasite persistence and infla...