Cover Image

Safety, Tolerability, and Pharmacokinetics of Benralizumab: A Phase 1, Randomized, Single-Blind Study of Healthy Chinese Participants

Tommy Tsang Cheung,1,&ast; Tu H Mai,2,&ast; Yen Lin Chia,2 Desmond YH Yap,1 Chi-Ho Lee,1 Cecil Chi-Keung Chen,2 Ying Huang,3 Yuwen Jin,3 James Johnston,4 Viktoria Werkström,5 Yuhui Yao,6 Xiaoyun Ge,7 Wenying Zheng8 1Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Ho...

Full description

Saved in:

Bibliographic Details
Main Authors:	Cheung TT (Author), Mai TH (Author), Chia YL (Author), Yap DYH (Author), Lee CH (Author), Chen CC (Author), Huang Y (Author), Jin Y (Author), Johnston J (Author), Werkström V (Author), Yao Y (Author), Ge X (Author), Zheng W (Author)
Format:	Book
Published:	Dove Medical Press, 2023-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Safety, Tolerability, and Pharmacokinetics of Adrenomedullin in Healthy Males: A Randomized, Double-Blind, Phase 1 Clinical Trial
by: Kita T, et al.
Published: (2020)

Population Pharmacokinetics and Pharmacodynamics of Benralizumab in Healthy Volunteers and Patients With Asthma
by: B Wang, et al.
Published: (2017)

Treatment of Widespread Eosinophilic Cellulitis (Wells' Syndrome) with Benralizumab
by: Maria Blomberg, et al.
Published: (2020)

Perspectives on the Efficacy of Benralizumab for Treatment of Eosinophilic Granulomatosis With Polyangiitis
by: Yasuhiko Koga, et al.
Published: (2022)

Safety, tolerability, pharmacokinetics, and pharmacodynamics of HBM9161, a novel FcRn inhibitor, in a phase I study for healthy Chinese volunteers
by: Desmond Y. H. Yap, et al.
Published: (2021)

Safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of aficamten in healthy Chinese participants: a randomized, double-blind, placebo-controlled, phase 1 study
by: Xue Zhao, et al.
Published: (2023)

A case of paradoxical eosinophilic fasciitis in a patient on benralizumab
by: Michael J. Woodbury, BS, et al.
Published: (2023)

Mabs for treating asthma: omalizumab, mepolizumab, reslizumab, benralizumab, dupilumab
by: Erminia Ridolo, et al.
Published: (2020)

Safety, tolerability and pharmacokinetics of WXFL10203614 in healthy Chinese subjects: A randomized, double-blind, placebo-controlled phase Ⅰ study
by: Kai Huang, et al.
Published: (2022)

Pharmacokinetics, safety, and tolerability of inhaled remdesivir in healthy participants
by: Rita Humeniuk, et al.
Published: (2023)

A phase I, randomized study to evaluate the safety, tolerability, and pharmacokinetics of mefunidone in healthy subjects
by: Mai Han, et al.
Published: (2024)

Benralizumab in the treatment of severe asthma: design, development and potential place in therapy
by: Pelaia C, et al.
Published: (2018)

A Phase 1, Randomized, Double-Blind, Single-Dose, Placebo-Controlled Safety, Tolerability, And Pharmacokinetic/Pharmacodynamic Study Of Evolocumab In Healthy Chinese Subjects
by: Liu C, et al.
Published: (2019)

A phase I randomized, double‐blind, single subcutaneous dose escalation study to determine the safety, tolerability, and pharmacokinetics of rezafungin in healthy adult subjects
by: Kenan Gu, et al.
Published: (2022)

Safety, tolerance, and pharmacokinetics of salvianolic acid B in healthy Chinese volunteers: A randomized, double-blind, placebo-controlled phase 1 clinical trial
by: Junlin Cheng, et al.
Published: (2023)

Efficacy and steroid-sparing effect of benralizumab: has it an advantage over its competitors?
by: Francesco Menzella, et al.
Published: (2019)

Pharmacoeconomic analysis of using benralizumab for treatment of severe asthma in inpatient and outpatient settings
by: M. V. Zhuravleva, et al.
Published: (2022)

Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers
by: Mohammad Al‐Mahdi Al‐Karagholi, et al.
Published: (2021)

Case Report: Eosinophilic Bronchiolitis With Eosinophil ETosis in Mucus Plugs Successfully Treated With Benralizumab
by: Hisashi Sasaki, et al.
Published: (2022)

Phase I study in healthy participants to evaluate safety, tolerability, and pharmacokinetics of inhaled nezulcitinib, a potential treatment for COVID‐19
by: Nathan D. Pfeifer, et al.
Published: (2021)

A Phase 1 Study to Assess the Pharmacokinetics, Food Effect, Safety, and Tolerability of Sepiapterin in Healthy Japanese and Non-Japanese Participants
by: Lan Gao, et al.
Published: (2024)

A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects
by: Qian H, et al.
Published: (2021)

A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Novel Intravenous Formulation of Meloxicam (QP001) in Healthy Chinese Subjects
by: Ma J, et al.
Published: (2023)

Pharmacokinetics and Tolerability of Single and Multiple Intravenous Doses of Cefotetan Disodium in Healthy Chinese Volunteers
by: Liu J, et al.
Published: (2020)

Safety, tolerability, pharmacokinetics, and pharmacodynamics of a soluble guanylate cyclase stimulator, HEC95468, in healthy volunteers: a randomized, double-blinded, placebo-controlled phase 1 trial
by: Yu-zhou Gui, et al.
Published: (2024)

A Phase 1 first‐in‐human study of the safety, tolerability, and pharmacokinetics of the ROBO2 fusion protein PF‐06730512 in healthy participants
by: Chay Ngee Lim, et al.
Published: (2021)

Treatment-Refractory Eosinophilic Esophagitis Successfully Managed with benralizumab: A Case Presentation and literature review
by: Petrousis Grigorios, et al.
Published: (2024)

Pharmacokinetics, Safety, and Preliminary Efficacy of Oral Trifluridine/Tipiracil in Chinese Patients with Solid Tumors: A Phase 1b, Open-Label Study
by: Wang X, et al.
Published: (2020)

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Sotagliflozin After Multiple Ascending Doses in Chinese Healthy Subjects
by: He X, et al.
Published: (2022)

A phase 1, randomized, double‐blind, placebo‐controlled study to evaluate the safety, tolerability, and pharmacokinetics of single and multiple doses of lisdexamfetamine dimesylate in Japanese and Caucasian healthy adult subjects
by: James Ermer, et al.
Published: (2020)

Dupilumab treatment of a case of asthma, chronic rhinosinusitis, and atopic dermatitis after initial benralizumab administration
by: Haruna Matsuda‐Hirose, et al.
Published: (2020)

Effectiveness of Benralizumab in Improving the Quality of Life of Severe Eosinophilic Asthmatic Patients: Our Real-Life Experience
by: Giulia Scioscia, et al.
Published: (2021)

Analysis of the clinical and economic effectiveness of using benralizumab in comparison with standard therapy in patients with severe bronchial asthma
by: S. V. Nedogoda, et al.
Published: (2024)

Exploring the pharmacokinetics and tolerability of cyclooxygenase inhibitor ampiroxicam: a phase I study on single and multiple oral doses
by: Pengfei Zhao, et al.
Published: (2024)

A phase I, first‐in‐human study investigating the safety, tolerability, and pharmacokinetics of the maturation inhibitor GSK3739937
by: Paul D. Benn, et al.
Published: (2023)

The Maximum-Tolerated Dose and Pharmacokinetics of a Novel Chemically Modified Curcumin in Rats
by: Bhatt HD, et al.
Published: (2022)

Phase I studies of the safety, tolerability, pharmacokinetics, and pharmacodynamics of DS‐1211, a tissue‐nonspecific alkaline phosphatase inhibitor
by: Sonomi Maruyama, et al.
Published: (2022)

Phase I and scintigraphy studies to evaluate safety, tolerability, pharmacokinetics, and lung deposition of inhaled GDC‐0214 in healthy volunteers
by: Rui Zhu, et al.
Published: (2022)

Phase I evaluation of the safety, tolerability, and pharmacokinetics of GSK3640254, a next‐generation HIV‐1 maturation inhibitor
by: Samit R. Joshi, et al.
Published: (2020)

Phase I Trial of Pyragrel, a Novel Thromboxane Synthetase Inhibitor, to Evaluate the Safety, Tolerability, and Pharmacokinetics in Healthy Volunteers
by: Chan Zou, et al.
Published: (2019)