Inflammatory injury to the neonatal brain - what can we do?
Abstract <br/>Perinatal brain damage is one of the leading causes of life long disability. This damage could be hypoxic-ischemic, inflammatory or both.<br/>This mini-review discusses different interventions aiming at minimizing inflammatory processes in the neonatal brain, both before an...
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| Main Authors: | , |
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| Format: | Book |
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Frontiers Media S.A.,
2014-04-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Abstract <br/>Perinatal brain damage is one of the leading causes of life long disability. This damage could be hypoxic-ischemic, inflammatory or both.<br/>This mini-review discusses different interventions aiming at minimizing inflammatory processes in the neonatal brain, both before and after insult. <br/>Current options of anti-inflammatory measures for neonates remain quite limited. <br/>We describe current anti-inflammatory intervention strategies such as avoiding perinatal infection and inflammation, and reducing exposure to inflammatory processes. We describe the known effects of anti-inflammatory drugs such as steroids, antibiotics, and indomethacin, and the possible anti-inflammatory role of other substances such as IL-1receptor antagonists, erythropoietin, caffeine, estradiol, insulin like growth factor and melatonin as well as endogenous protectors, and genetic regulation of inflammation. <br/>If successful, these may decrease mortality and long term morbidity among term and preterm infants.<br/> |
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| Item Description: | 2296-2360 10.3389/fped.2014.00030 |