N-terminal selective conjugation method widens the therapeutic window of antibody-drug conjugates by improving tolerability and stability

• Main Authors: Min Ji Ko (Author), Daehae Song (Author), Juhee Kim (Author), Jae Yong Kim (Author), Jaehyun Eom (Author), Byungje Sung (Author), Yong-Gyu Son (Author), Young Min Kim (Author), Sang Hoon Lee (Author), Weon-Kyoo You (Author), Jinwon Jung (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antibody-drug conjugates (ADCs) are targeted therapeutic agents that treat cancers by selective delivery of highly potent cytotoxic drugs to tumor cells via cancer-specific antibodies. However, their clinical benefit is limited by off-target toxicity and narrow therapeutic windows. To overcome these...