Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes

• Main Authors: Eva Lana-Elola (Author), Heather Cater (Author), Sheona Watson-Scales (Author), Simon Greenaway (Author), Jennifer Müller-Winkler (Author), Dorota Gibbins (Author), Mihaela Nemes (Author), Amy Slender (Author), Tertius Hough (Author), Piia Keskivali-Bond (Author), Cheryl L. Scudamore (Author), Eleanor Herbert (Author), Gareth T. Banks (Author), Helene Mobbs (Author), Tara Canonica (Author), Justin Tosh (Author), Suzanna Noy (Author), Miriam Llorian (Author), Patrick M. Nolan (Author), Julian L. Griffin (Author), Mark Good (Author), Michelle Simon (Author), Ann-Marie Mallon (Author), Sara Wells (Author), Elizabeth M. C. Fisher (Author), Victor L. J. Tybulewicz (Author)
• Format: Book
• Published: The Company of Biologists, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Down syndrome (DS), trisomy 21, results in many complex phenotypes including cognitive deficits, heart defects and craniofacial alterations. Phenotypes arise from an extra copy of human chromosome 21 (Hsa21) genes. However, these dosage-sensitive causative genes remain unknown. Animal models enable...