Deletion of TNFAIP6 Gene in Human Keratinocytes Demonstrates a Role for TSG-6 to Retain Hyaluronan Inside Epidermis

• Main Authors: Céline Evrard (Author), Emilie Faway (Author), Evelyne De Vuyst (Author), Olivier Svensek (Author), Valérie De Glas (Author), David Bergerat (Author), Michel Salmon (Author), Olivier De Backer (Author), Bruno Flamion (Author), Hélène Le-Buanec (Author), Catherine Lambert de Rouvroit (Author), Yves Poumay (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

TSG-6 is a soluble protein secreted in the extracellular matrix by various cell types in response to inflammatory stimuli. TSG-6 interacts with extracellular matrix molecules, particularly hyaluronan (HA), and promotes cutaneous wound closure in mice. Between epidermal cells, the discrete extracellu...