Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice

• Main Authors: Tsuyoshi Yamamoto (Author), Mariko Harada-Shiba (Author), Moeka Nakatani (Author), Shunsuke Wada (Author), Hidenori Yasuhara (Author), Keisuke Narukawa (Author), Kiyomi Sasaki (Author), Masa-Aki Shibata (Author), Hidetaka Torigoe (Author), Tetsuji Yamaoka (Author), Takeshi Imanishi (Author), Satoshi Obika (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent findings in molecular biology implicate the involvement of proprotein convertase subtilisin/kexin type 9 (PCSK9) in low-density lipoprotein receptor (LDLR) protein regulation. The cholesterol-lowering potential of anti-PCSK9 antisense oligonucleotides (AONs) modified with bridged nucleic acid...