REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA
Methylated analogs of L-arginine - asymmetric dimetilarginin (ADMA) and monometilarginin (L-NMMA) - are endogenous inhibitors of endothelial NO-synthase (eNOS). ADMA level in maternal plasma is increased in women with preeclampsia. The high level of ADMA is one of the predictors of preeclampsia. L-a...
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Столичная издательская компания,
2016-01-01T00:00:00Z.
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| 001 | doaj_2e2d0fe97be247eeb5bcd3a592b1aee3 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a M. V. Pokrovsky |e author |
| 700 | 1 | 0 | |a N. G. Filipenko |e author |
| 700 | 1 | 0 | |a M. V. Korokin |e author |
| 700 | 1 | 0 | |a V. V. Gureyev |e author |
| 700 | 1 | 0 | |a T. G. Pokrovsky |e author |
| 700 | 1 | 0 | |a A. A. Barsuk |e author |
| 700 | 1 | 0 | |a L. V. Korokina |e author |
| 700 | 1 | 0 | |a E. V. Proskuryakova |e author |
| 700 | 1 | 0 | |a N. V. Maltseva |e author |
| 700 | 1 | 0 | |a O. V. Levashova |e author |
| 700 | 1 | 0 | |a O. S. Gudyrev |e author |
| 700 | 1 | 0 | |a A. S. Belous |e author |
| 700 | 1 | 0 | |a O. S. Polyanskaya |e author |
| 245 | 0 | 0 | |a REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA |
| 260 | |b Столичная издательская компания, |c 2016-01-01T00:00:00Z. | ||
| 500 | |a 1819-6446 | ||
| 500 | |a 2225-3653 | ||
| 500 | |a 10.20996/1819-6446-2010-6-6-882-887 | ||
| 520 | |a Methylated analogs of L-arginine - asymmetric dimetilarginin (ADMA) and monometilarginin (L-NMMA) - are endogenous inhibitors of endothelial NO-synthase (eNOS). ADMA level in maternal plasma is increased in women with preeclampsia. The high level of ADMA is one of the predictors of preeclampsia. L-arginine increases the activity of eNOS and production of nitric oxide in the ADMA-similar model of L-NAME-induced endothelial dysfunction. ENOS activator (resveratrol), antioxidants, potentiated polyclonal antibodies to eNOS and others agents have been effective in this model. Studies of endotelioprotective activity in other «ADMA-eNOS-associated" experimental models of metabolic syndrome and homocysteine-induced, gipoestrogen-induced sepsis-induced endothelial dysfunction and endothelial dysfunction in postvaccinal vasculitis have been developed. | ||
| 546 | |a EN | ||
| 546 | |a RU | ||
| 690 | |a endothelial dysfunction | ||
| 690 | |a preeclampsia | ||
| 690 | |a adma | ||
| 690 | |a enos | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 690 | |a Diseases of the circulatory (Cardiovascular) system | ||
| 690 | |a RC666-701 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Рациональная фармакотерапия в кардиологии, Vol 6, Iss 6, Pp 882-887 (2016) | |
| 787 | 0 | |n https://www.rpcardio.online/jour/article/view/938 | |
| 787 | 0 | |n https://doaj.org/toc/1819-6446 | |
| 787 | 0 | |n https://doaj.org/toc/2225-3653 | |
| 856 | 4 | 1 | |u https://doaj.org/article/2e2d0fe97be247eeb5bcd3a592b1aee3 |z Connect to this object online. |