D2-40/podoplanin expression in chronic villitis of the placenta

• Main Authors: Erika S. Abu Egal (Author), Juliana S. Nascimento (Author), Fernanda Meireles (Author), Amílcar C. Mattos (Author), Harim T. Santos (Author), Fernanda Viviane Mariano (Author), Albina M. A. M. Altemani (Author)
• Format: Book
• Published: Sociedade Brasileira de Patologia Clínica, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1678-4774; 10.5935/1676-2444.20180022
• Keywords: placenta; immunohistochemistry; stromal cells; Pathology; RB1-214
• Source: Jornal Brasileiro de Patologia e Medicina Laboratorial, Vol 54, Iss 2, Pp 116-119 (2018)

ABSTRACT D2-40/podoplanin (D2-40/PDPN) is a multifunctional protein that can be expressed in lymphatic endothelium and immune cells. D2-40/ PDPN expression in chronic villitis (CV) has not been studied. In 22 cases of CV, we analyzed both D2-40/PDPN expression as well as its coexpression with immune cells markers, and the relationship with stromal cells. In the non-inflamed villi, the D2-40/PDPN positive plexiform pattern has a lymphatic-like conductive network. In the inflamed villi, the D2-40/PDPN expression, predominantly restricted to stromal cells forming a cellular network, is likely related to a phase of the inflammatory response, such as reorganization of the damaged tissue.