6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation

A novel series of aminotrimethylpyridinol and aminodimethylpyrimidinol derivatives were designed and synthesised for FGFR4 inhibitors. Structure-activity relationship on the FGFR4 inhibitory activity of the new compounds was clearly elucidated by an intensive molecular docking study. Anti-cancer act...

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Autores principales: Chhabi Lal Chaudhary (Autor), Dongchul Lim (Autor), Prakash Chaudhary (Autor), Diwakar Guragain (Autor), Bhuwan Prasad Awasthi (Autor), Hee Dong Park (Autor), Jung-Ae Kim (Autor), Byeong-Seon Jeong (Autor)
Formato: Libro
Publicado: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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