6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation
A novel series of aminotrimethylpyridinol and aminodimethylpyrimidinol derivatives were designed and synthesised for FGFR4 inhibitors. Structure-activity relationship on the FGFR4 inhibitory activity of the new compounds was clearly elucidated by an intensive molecular docking study. Anti-cancer act...
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Autores principales: | , , , , , , , |
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Formato: | Libro |
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Taylor & Francis Group,
2022-12-01T00:00:00Z.
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Acceso en línea: | Connect to this object online. |
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Número de Clasificación: |
A1234.567 |
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