SARS-CoV-2 infection during pregnancy and pregnancy-related conditions: Concerns, challenges, management and mitigation strategies-a narrative review

• Main Authors: Rakesh Kumar (Author), Cut Meurah Yeni (Author), Niken Asri Utami (Author), Rupali Masand (Author), Rajesh Kumar Asrani (Author), Shailesh Kumar Patel (Author), Akshay Kumar (Author), Mohd. Iqbal Yatoo (Author), Ruchi Tiwari (Author), Senthilkumar Natesan (Author), Kranti Suresh Vora (Author), Firzan Nainu (Author), Muhammad Bilal (Author), Manish Dhawan (Author), Talha Bin Emran (Author), Tauseef Ahmad (Author), Harapan Harapan (Author), Kuldeep Dhama (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health problem. The SARS-CoV-2 triggers hyper-activation of inflammatory and immune responses resulting in cytokine storm and increased inflammatory responses on several organs like lungs, kidneys, intestine, and placenta. Although SARS-CoV-2 affects individuals of all age groups and physiological statuses, immune-compromised individuals such as pregnant women are considered as a highly vulnerable group. This review aims to raise the concerns of high risk of infection, morbidity and mortality of COVID-19 in pregnant women and provides critical reviews of pathophysiology and pathobiology of how SARS-CoV-2 infection potentially increases the severity and fatality during pregnancy. This article also provides a discussion of current evidence on vertical transmission of SARS-CoV-2 during pregnancy and breastfeeding. Lastly, guidelines on management, treatment, preventive, and mitigation strategies of SARS-CoV-2 infection during pregnancy and pregnancy-related conditions such as delivery and breastfeeding are discussed.

Item Description

1876-0341
10.1016/j.jiph.2021.04.005