NUDT15 Genetic Variants in Chinese Han, Uighur, Kirghiz, and Dai Nationalities

• Main Authors: Fang Zhang (Author), Gulbanur Amat (Author), Yanjing Tang (Author), Ru Chen (Author), Xin Tian (Author), Wenting Hu (Author), Changcheng Chen (Author), Shuhong Shen (Author), Yangyang Xie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundThiopurines are widely used as anti-cancer and immunosuppressant agents, but have a narrow therapeutic index owing to frequent toxicity and life-threatening bone marrow suppression. The nudix hydrolase 15 (NUDT15) genetic polymorphism is strongly associated with the tolerance and myelosupp...