Associations between the <i>C3orf20</i> rs12496846 Polymorphism and Both Postoperative Analgesia after Orthognathic and Abdominal Surgeries and <i>C3orf20</i> Gene Expression in the Brain

Considerable individual differences are widely observed in the sensitivity to opioid analgesics. We focused on rs12496846, rs698705, and rs10052295 single-nucleotide polymorphisms (SNPs) in the <i>C3orf20</i>, <i>SLC8A2</i>, and <i>CTNND2</i> gene regions that we...

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Main Authors: Daisuke Nishizawa (Author), Makoto Nagashima (Author), Shinya Kasai (Author), Junko Hasegawa (Author), Kyoko Nakayama (Author), Yuko Ebata (Author), Ken-ichi Fukuda (Author), Tatsuya Ichinohe (Author), Masakazu Hayashida (Author), Kazutaka Ikeda (Author)
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Published: MDPI AG, 2022-03-01T00:00:00Z.
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001 doaj_2f60f3ea7d5b4a98ad7a280d60ece0a6
042 |a dc 
100 1 0 |a Daisuke Nishizawa  |e author 
700 1 0 |a Makoto Nagashima  |e author 
700 1 0 |a Shinya Kasai  |e author 
700 1 0 |a Junko Hasegawa  |e author 
700 1 0 |a Kyoko Nakayama  |e author 
700 1 0 |a Yuko Ebata  |e author 
700 1 0 |a Ken-ichi Fukuda  |e author 
700 1 0 |a Tatsuya Ichinohe  |e author 
700 1 0 |a Masakazu Hayashida  |e author 
700 1 0 |a Kazutaka Ikeda  |e author 
245 0 0 |a Associations between the <i>C3orf20</i> rs12496846 Polymorphism and Both Postoperative Analgesia after Orthognathic and Abdominal Surgeries and <i>C3orf20</i> Gene Expression in the Brain 
260 |b MDPI AG,   |c 2022-03-01T00:00:00Z. 
500 |a 10.3390/pharmaceutics14040727 
500 |a 1999-4923 
520 |a Considerable individual differences are widely observed in the sensitivity to opioid analgesics. We focused on rs12496846, rs698705, and rs10052295 single-nucleotide polymorphisms (SNPs) in the <i>C3orf20</i>, <i>SLC8A2</i>, and <i>CTNND2</i> gene regions that we previously identified as possibly associated with postoperative analgesia after orthognathic surgery. We investigated associations between these SNPs and postoperative analgesia in 112 patients who underwent major open abdominal surgery in hospitals and were treated with analgesics, including opioids, after surgery. Total genomic DNA was extracted from peripheral blood or oral mucosa samples for genotyping each SNP. Effects of these potent SNPs on gene expression in the brain were also investigated in samples that were provided by the Stanley Foundation Brain Bank. In the association studies, carriers of the G allele of the rs12496846 SNP in the <i>C3orf20</i> gene region were significantly associated with greater 24 h postoperative analgesic requirements among the three SNPs that were investigated (<i>p</i> = 0.0015), which corroborated a previous study of orthognathic patients (<i>p</i> < 0.0001). In the gene expression analysis, carriers of the G allele of the rs12496846 SNP were significantly associated with lower mRNA expression of the <i>C3orf20</i> gene (<i>p</i> < 0.0001). These results indicate that this SNP could serve as a marker that predicts analgesic requirements. 
546 |a EN 
690 |a opioids 
690 |a analgesics 
690 |a single-nucleotide polymorphisms 
690 |a orthognathic surgery 
690 |a abdominal surgery 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Pharmaceutics, Vol 14, Iss 4, p 727 (2022) 
787 0 |n https://www.mdpi.com/1999-4923/14/4/727 
787 0 |n https://doaj.org/toc/1999-4923 
856 4 1 |u https://doaj.org/article/2f60f3ea7d5b4a98ad7a280d60ece0a6  |z Connect to this object online.