Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia

• Main Authors: Shu-Tao Xie (Author), Wen-Chu Fan (Author), Xian-Sen Zhao (Author), Xiao-Yang Ma (Author), Ze-Lin Li (Author), Yan-Ran Zhao (Author), Fa Yang (Author), Ying Shi (Author), Hui Rong (Author), Zhi-San Cui (Author), Jun-Yi Chen (Author), Hong-Zhao Li (Author), Chao Yan (Author), Qipeng Zhang (Author), Jian-Jun Wang (Author), Xiao-Yang Zhang (Author), Xiao-Ping Gu (Author), Zheng-Liang Ma (Author), Jing-Ning Zhu (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Specific medications to combat cerebellar ataxias, a group of debilitating movement disorders characterized by difficulty with walking, balance and coordination, are still lacking. Notably, cerebellar microglial activation appears to be a common feature in different types of ataxic patients and rode...