Influenza vaccine effectiveness among high-risk groups: A systematic literature review and meta-analysis of case-control and cohort studies

Vaccination represents the most effective intervention to prevent infection, hospitalization and mortality due to influenza. This meta-analysis quantifies data reporting influenza vaccine effectiveness (VE) on influenza visits and hospitalizations of case-control and cohort studies among high-risk g...

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Main Authors: Vincenzo Restivo (Author), Claudio Costantino (Author), Stefania Bono (Author), Marialuisa Maniglia (Author), Valentina Marchese (Author), Gianmarco Ventura (Author), Alessandra Casuccio (Author), Fabio Tramuto (Author), Francesco Vitale (Author)
Format: Book
Published: Taylor & Francis Group, 2018-03-01T00:00:00Z.
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100 1 0 |a Vincenzo Restivo  |e author 
700 1 0 |a Claudio Costantino  |e author 
700 1 0 |a Stefania Bono  |e author 
700 1 0 |a Marialuisa Maniglia  |e author 
700 1 0 |a Valentina Marchese  |e author 
700 1 0 |a Gianmarco Ventura  |e author 
700 1 0 |a Alessandra Casuccio  |e author 
700 1 0 |a Fabio Tramuto  |e author 
700 1 0 |a Francesco Vitale  |e author 
245 0 0 |a Influenza vaccine effectiveness among high-risk groups: A systematic literature review and meta-analysis of case-control and cohort studies 
260 |b Taylor & Francis Group,   |c 2018-03-01T00:00:00Z. 
500 |a 2164-5515 
500 |a 2164-554X 
500 |a 10.1080/21645515.2017.1321722 
520 |a Vaccination represents the most effective intervention to prevent infection, hospitalization and mortality due to influenza. This meta-analysis quantifies data reporting influenza vaccine effectiveness (VE) on influenza visits and hospitalizations of case-control and cohort studies among high-risk groups. A systematic literature review including original articles published between 2007 and 2016, using a protocol registered on Prospero with No. 42017054854, and a meta-analysis were conducted. For 3 high-risk groups (subjects with underlying health conditions, pregnant women and health care workers) only a qualitative evaluation was performed. The VE quantitative analysis demonstrated a clear significant overall effect of 39% (95%CI: 32-46%) for visits and 57% (95%CI: 30-74%) for hospitalization among children. Considering the elderly influenza VE had a clear effect of 25% (95%CI: 6-40%) for visits and 14% (95%CI: 7-21%; p<0.001) for hospitalization. This study showed the high VE of influenza vaccination among high-risk groups, representing a tool for public health decision-makers to develop evidence-based preventive interventions to avoid influenza outcomes. 
546 |a EN 
690 |a children 
690 |a chronic disease 
690 |a effectiveness 
690 |a elderly subjects 
690 |a health care worker 
690 |a hospitalization 
690 |a influenza 
690 |a pregnancy 
690 |a vaccine 
690 |a visit 
690 |a Immunologic diseases. Allergy 
690 |a RC581-607 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Human Vaccines & Immunotherapeutics, Vol 14, Iss 3, Pp 724-735 (2018) 
787 0 |n http://dx.doi.org/10.1080/21645515.2017.1321722 
787 0 |n https://doaj.org/toc/2164-5515 
787 0 |n https://doaj.org/toc/2164-554X 
856 4 1 |u https://doaj.org/article/2f7ed32e5e4b415d9e7f83c93bb36f93  |z Connect to this object online.