Beneficial Effect of Scutellaria baicalensis Georgi Extract on Mercury Chloride-Induced Membrane Transport Dysfunction in Rabbit Renal Cortical Slices

• Main Authors: Hong-Soo Kim (Author), Choon-Ho Song (Author)
• Format: Book
• Published: Korean Pharmacopuncture Institute, 2001-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3831/KPI.2001.4.2.049; 2093-6966; 2234-6856
• Keywords: Scutellaria baicalensis Georgi; HgCl2; Membrane transport dysfunction; Rabbit renal cortical slice; PAH uptake; Na+─K+─ATPase activity; ATP; Medicine; R; Miscellaneous systems and treatments; RZ409.7-999; Therapeutics. Pharmacology; RM1-950
• Source: Journal of Pharmacopuncture, Vol 4, Iss 2, Pp 49-56 (2001)

This study was undertaken to determine whether Scutellaria baicalensis Georgi (SbG) extract exerts the protective effect against HgCl2-induced alterations in membrane transport function in rabbit renal cortical slices. The slices were treated with 0.1 mM HgCl2 for 60 min at . 37℃. HgCl2 caused an inhibition in PAH uptake by renal cortical slices. Such an effect was accompanied by depressed Na+ ─ K+ATPase activity and ATP depletion. SbG prevented HgCl2-induced inhibition of PAH uptake in a dose-dependent manner at the concentration ranges of 0.01-0.1%. HgCl2-induced inhibition of Na+ ─ K+-ATPase activity and ATP depletion were significantly prevented by 0.05% SbG. These results suggest that SbG prevents HgCl2-induced alterations in membrane transport function in rabbit renal cortical slices. Such protective effects of SbG may be attributed to inhibition of peroxidation of membrane lipid.