A Cre-driver rat model for anatomical and functional analysis of glucagon (Gcg)-expressing cells in the brain and periphery

• Main Authors: Huiyuan Zheng (Author), Lorena López-Ferreras (Author), Jean-Phillipe Krieger (Author), Stephen Fasul (Author), Valentina Cea Salazar (Author), Natalia Valderrama Pena (Author), Karolina P. Skibicka (Author), Linda Rinaman (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The glucagon gene (Gcg) encodes preproglucagon, which is cleaved to form glucagon-like peptide 1 (GLP1) and other mature signaling molecules implicated in metabolic functions. To date there are no transgenic rat models available for precise manipulation of GLP1-expressing cells in the bra...