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The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models

Heterozygous mutations in the GBA1 gene - encoding lysosomal glucocerebrosidase (GCase) - are the most common genetic risk factors for Parkinson's disease (PD). Experimental evidence suggests a correlation between decreased GCase activity and accumulation of alpha-synuclein (aSyn). To enable a...

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Main Authors:	Nicole K. Polinski (Author), Terina N. Martinez (Author), Sylvie Ramboz (Author), Michael Sasner (Author), Mark Herberth (Author), Robert Switzer (Author), Syed O. Ahmad (Author), Lee J. Pelligrino (Author), Sean W. Clark (Author), Jacob N. Marcus (Author), Sean M. Smith (Author), Kuldip D. Dave (Author), Mark A. Frasier (Author)
Format:	Book
Published:	The Company of Biologists, 2022-06-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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