SEX DIFFERENCES IN QUALITY OF LIFE IN PATIENTS WITH ISCHEMIA WITH NO OBSTRUCTIVE CORONARY ARTERIES (INOCA): A PATIENT SELF-REPORT SURVEY FROM INOCA INTERNATIONAL

• Main Authors: Sachini Ranasinghe, MD MPH (Author), Najah Khan, MD (Author), C. Noel Bairey Merz, MD (Author), Janet Wei, MD (Author), Maria George (Author), Colin Berry, MD (Author), Alaide Chieffo, MD (Author), Paolo G Camici, MD (Author), Filippo Crea, MD (Author), Juan-Carlos Kaski, DSc, MD (Author), Mario Marzilli, MD (Author), Martha Gulati, MD MS (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Therapeutic Area: ASCVD/CVD in Women Background: Women with obstructive coronary artery disease (CAD) have a relatively lower quality of life (QoL) compared to men but our understanding of sex differences in QoL in ischemia with no obstructive coronary artery disease (INOCA) is limited. Methods: We conducted a survey of patient members of INOCA International with an assessment of self-reported health measures. Functional capacity was retrospectively estimated using the Duke Activity Status Index (DASI) assessing levels of activities performed before and after INOCA symptom onset. Results: Of the 1579 patient members of INOCA International, the overall survey completion rate was 21%. Women represented 91% of the respondents. Estimated functional capacity, expressed as metabolic equivalents (METs), was higher before compared to after INOCA diagnosis for comparably for both women (8.6±1.8 METs vs. 5.6±1.8 METs respectively, p<0.00001) and men (8.7 ± 2.0 METs vs. 6.1 ± 1.8 METs respectively, p<0.00001). For every 1 MET decline in functional capacity, there was a significantly greater decline in QoL for men compared with women in physical health (4.0±1.1 vs. 2.9±0.3 days/month, P<0.001), mental health (2.4 ±1.2 vs. 1.8±0.3 days/month, P=0.001), and social health/recreational activities (4.1 ±1.0 vs. 2.9 ±0.3 days/month, P=0.0001), respectively (Figure 1). Conclusions: In an international INOCA survey, despite similar diagnoses, clinical comorbidities, symptoms, and quality of life, INOCA-related functional capacity declines are associated with a greater adverse impact on QoL in men compared to women. These findings highlight the need for future studies to include QoL measures in INOCA treatment strategies stratified by sex.

Item Description

2666-6677
10.1016/j.ajpc.2023.100549